Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Genome-wide analysis of the miR profile in human head and neck paraganglioma vs. Jacobson's (tympanic) nerve and SH-SY5Y neuroblastoma cells

ABSTRACT: The aim of the study was to assess whether changes in the expression of miRs could be implicated in the modulation of the NOTCH pathway in head and neck paragangliomas. Several miRs, notably including families (miR-34s, miR-200s) that target the NOTCH signaling pathway, resulted differentially expressed in paragangliomas compared to the reference normal tissue, i.e., Jacobson's nerve. Total RNA from paraganglioma samples compared to total RNA from Jacobson's nerves (normal controls, chosen because Jacobson's nerve is a frequent site of origin of tympanic paraganglioma) and from SH-SY5Y cells (chosen based on their sympathoadrenal origin).

ORGANISM(S): Homo sapiens

SUBMITTER: Renato Mariani-Costantini 

PROVIDER: E-GEOD-49190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density genome-wide copy number variation (CNV) analysis with microRNA and immunomorphological studies. Gene-centric CNV analysis of 24 cases identified a list of 104 genes most significantly  ...[more]

Similar Datasets

Genomics Genome-wide analysis of the miR profile in human head and neck paraganglioma vs. Jacobson's (tympanic) nerve and SH-SY5Y neuroblastoma cells
2013-08-21 | GSE49190 | GEO
Transcriptomics High-density genome-wide copy number variation (CNV) in human head and neck paragangliomas.
2013-08-21 | E-GEOD-49614 | biostudies-arrayexpress
Transcriptomics GE/miRNA expression profile of Human Epicardial Adipose Tissue (EAT) and Subcutaneous Adipose Tissue (SAT) in Patients with Coronary Artery Disease (CAD) vs. Controls (CTRL)
2015-11-22 | E-GEOD-64566 | biostudies-arrayexpress
Transcriptomics GE/miRNA expression profile of Human Epicardial Adipose Tissue (EAT) and Subcutaneous Adipose Tissue (SAT) in Patients with Coronary Artery Disease (CAD) vs. Controls (CTRL) - PART 1 - Genes
2015-11-22 | E-GEOD-64554 | biostudies-arrayexpress
Transcriptomics GE/miRNA expression profile of Human Epicardial Adipose Tissue (EAT) and Subcutaneous Adipose Tissue (SAT) in Patients with Coronary Artery Disease (CAD) vs. Controls (CTRL) - PART 2 - miRNA
2015-11-22 | E-GEOD-64563 | biostudies-arrayexpress
Transcriptomics Head and neck paragangliomas
2013-08-21 | E-GEOD-49615 | biostudies-arrayexpress
Genomics High-density genome-wide copy number variation (CNV) in human head and neck paragangliomas.
2013-08-21 | GSE49614 | GEO
Transcriptomics Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas
2008-12-10 | E-GEOD-12921 | biostudies-arrayexpress
Transcriptomics Gene expression analysis of a paraganglioma sample carrying the DLST-p.Y422C mutation
2023-05-05 | GSE210808 | GEO
Transcriptomics Similar gene expression profiles of sporadic, PGL2-, and SDHD-linked paragangliomas
2008-12-10 | GSE12921 | GEO