Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Renato Mariani-Costantini
PROVIDER: E-GEOD-49615 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cama Alessandro A Verginelli Fabio F Lotti Lavinia Vittoria LV Napolitano Francesco F Morgano Annalisa A D'Orazio Andria A Vacca Michele M Perconti Silvia S Pepe Felice F Romani Federico F Vitullo Francesca F di Lella Filippo F Visone Rosa R Mannelli Massimo M Neumann Hartmut P H HP Raiconi Giancarlo G Paties Carlo C Moschetta Antonio A Tagliaferri Roberto R Veronese Angelo A Sanna Mario M Mariani-Costantini Renato R
Acta neuropathologica 20130818 4
Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density genome-wide copy number variation (CNV) analysis with microRNA and immunomorphological studies. Gene-centric CNV analysis of 24 cases identified a list of 104 genes most significantly ...[more]