Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Head and neck paragangliomas


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Renato Mariani-Costantini 

PROVIDER: E-GEOD-49615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Head and neck paragangliomas, rare neoplasms of the paraganglia composed of nests of neurosecretory and glial cells embedded in vascular stroma, provide a remarkable example of organoid tumor architecture. To identify genes and pathways commonly deregulated in head and neck paraganglioma, we integrated high-density genome-wide copy number variation (CNV) analysis with microRNA and immunomorphological studies. Gene-centric CNV analysis of 24 cases identified a list of 104 genes most significantly  ...[more]

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