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Expression profiling of PBMC from patients with hepatocellular carcinoma

ABSTRACT: Aberrant gene expression analysis between peripheral blood mononuclear cell (PBMC) samples from healthy individuals and patients with pancreatic carcinoma, gastric carcinoma and hepatocellular carcinoma (HCC) were identified using Affymetrix gene arrays. Peripheral blood mononuclear cell (PBMC) from healthy individuals, patients with pancreatic carcinoma, gastric carcinoma and HCC were isolated and total RNA was extracted for Affymetrix gene microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Kam Hui

PROVIDER: E-GEOD-49515 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A blood-based three-gene signature for the non-invasive detection of early human hepatocellular carcinoma.

Shi Ming M Chen Min-Shan MS Sekar Karthik K Tan Chee-Kiat CK Ooi London Lucien LL Hui Kam M KM

European journal of cancer (Oxford, England : 1990) 20131211 5

<h4>Background</h4>Identifying early stages of disease in high-risk individuals for the development of hepatocellular carcinoma (HCC) would greatly improve the clinical outcomes of these individuals. The aim of this study was to develop a blood-based gene set that could identify early-stage HCC.<h4>Methods</h4>Comprehensive gene expression profiling of purified RNA of peripheral blood mononuclear cells (PBMC) was performed using microarrays. Gene signatures were developed through bioinformatics- ...[more]

PMID: 24332572

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