Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast
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ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Peter Park
PROVIDER: E-GEOD-49575 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast.
DeGennaro Christine M CM Alver Burak H BH Marguerat Samuel S Stepanova Ekaterina E Davis Christopher P CP Bähler Jürg J Park Peter J PJ Winston Fred F
Molecular and cellular biology 20131007 24
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression. To gain a comprehensive understanding of the roles of Spt6, we performed genome-wide analyses of transcription, chromatin structure, and histone modifications in a Schizosaccharomyces pombe spt6 mutant. Our results demonstrate dramatic changes to transcription and chromatin structure in the mutant, including elevated antisense transcripts at >70% of all genes ...[more]
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