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TARBP2 HITS-CLIP

ABSTRACT: In order to identify TARBP2 binding sites on endogenous RNA, we performed HITS-CLIP on a myc-tagged TARBP2 expressing cell-line (transient transfection) Cells were transfected with tagged TARBP2 vector (Origene) and 48-hr post-transfection, they were subjected to the HITS-CLIP procedure (Licatalosi D, et al. 2008, Nature 456:464-U22)

ORGANISM(S): Homo sapiens

SUBMITTER: Hani Goodarzi

PROVIDER: E-GEOD-49648 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins.

Goodarzi Hani H Zhang Steven S Buss Colin G CG Fish Lisa L Tavazoie Saeed S Tavazoie Sohail F SF

Nature 20140709 7517

Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability to fold into structures. However, the roles of structural mRNA elements in cancer progression remain unexplored. Here we performed an unbiased search for post-transcriptional modula ...[more]

PMID: 25043050

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Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-16 | E-GEOD-49649 | biostudies-arrayexpress

Homo sapiens

Project description:TARBP2 HITS-CLIP

| PRJNA214606 | ENA

TARBP2 HITS-CLIP

Project description:In order to identify TARBP2 binding sites on endogenous RNA, we performed HITS-CLIP on a myc-tagged TARBP2 expressing cell-line (transient transfection)

2014-07-24 | GSE49648 | GEO

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