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Gene expression profile of replicative senescence in normal human diploid fibroblasts.

ABSTRACT: Transcriptional profiling of normal human diploid fibroblasts(TIG-3) comparing late passage with early passage. Total RNA was isolated using TRIzol reagent and were analyzed using the human 3D-Gene DNA chip (Toray) that contains 25000 genes. The genome wide transcriptional response of senescent cells(more than 70 population doublings)(Replicative) were compared to that of proliferating cells(less than 40 population doublings)(Young).

ORGANISM(S): Homo sapiens

SUBMITTER: Satoshi Kondo

PROVIDER: E-GEOD-49860 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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