Oxidative metabolism and PGC-1 attenuate macrophage-mediated inflammation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Justin Odegaard
PROVIDER: E-GEOD-5003 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.
Vats Divya D Mukundan Lata L Odegaard Justin I JI Zhang Lina L Smith Kristi L KL Morel Christine R CR Wagner Roger A RA Greaves David R DR Murray Peter J PJ Chawla Ajay A
Cell metabolism 20060701 1
Complex interplay between T helper (Th) cells and macrophages contributes to the formation and progression of atherosclerotic plaques. While Th1 cytokines promote inflammatory activation of lesion macrophages, Th2 cytokines attenuate macrophage-mediated inflammation and enhance their repair functions. In spite of its biologic importance, the biochemical and molecular basis of how Th2 cytokines promote maturation of anti-inflammatory macrophages is not understood. We show here that in response to ...[more]
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