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Comparative analysis of mouse oral cancer cell lines

ABSTRACT: A comparative microarray analysis of indolent or aggressive mouse oral cancer cell lines was performed to identify gene expression signatures and specific molecules involved in aggressive tumor growth. We compared 3 indolent cell lines (MOC1, MOC22, MOC23) to 1 aggressive line and it's derivatives (MOC2, MOC2-7 and MOC2-10). We also included a cell line generated from a lymph node metastasis of the MOC2 tumor. The lines were all analyzed in triplicated except for MOC1 which was done in quadruplicate. Finally, we included duplicate samples of primary, normal C57BL/6 oral keratinocytes grown in the same media as the MOC cell lines.

ORGANISM(S): Mus musculus

SUBMITTER: ravindra uppaluri 

PROVIDER: E-GEOD-50041 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease.

Onken Michael D MD   Winkler Ashley E AE   Kanchi Krishna-Latha KL   Chalivendra Varun V   Law Jonathan H JH   Rickert Charles G CG   Kallogjeri Dorina D   Judd Nancy P NP   Dunn Gavin P GP   Piccirillo Jay F JF   Lewis James S JS   Mardis Elaine R ER   Uppaluri Ravindra R  

Clinical cancer research : an official journal of the American Association for Cancer Research 20140325 11

<h4>Purpose</h4>Improved understanding of the molecular basis underlying oral squamous cell carcinoma (OSCC) aggressive growth has significant clinical implications. Herein, cross-species genomic comparison of carcinogen-induced murine and human OSCCs with indolent or metastatic growth yielded results with surprising translational relevance.<h4>Experimental design</h4>Murine OSCC cell lines were subjected to next-generation sequencing (NGS) to define their mutational landscape, to define novel c  ...[more]

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