Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene expression changes resulting from the stable loss of BAP1 in uveal melanoma cell lines

ABSTRACT: Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactivating mutations in the tumor suppressor BAP1. The aim of this study was to investigate the role of BAP1 in uveal melanoma progression. To that end, uveal melanoma cells were studied following stable shRNA-mediated depletion of BAP1. RNA was isolated from three independent uveal melanoma cell lines each stably depleted using shRNA for either BAP1 or the control gene GFP. Two biological replicates were performed for each cell line.

ORGANISM(S): Homo sapiens

SUBMITTER: J.W. Harbour 

PROVIDER: E-GEOD-48863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma.

Matatall Katie A KA   Agapova Olga A OA   Onken Michael D MD   Worley Lori A LA   Bowcock Anne M AM   Harbour J William JW  

BMC cancer 20130805

<h4>Background</h4>Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactivating mutations in the tumor suppressor BAP1. The aim of this study was to investigate the role of BAP1 in uveal melanoma progression.<h4>Methods</h4>Uveal melanoma cells were studi  ...[more]

Similar Datasets

Transcriptomics Gene expression changes resulting from the stable loss of BAP1 in uveal melanoma cell lines
2013-09-06 | GSE48863 | GEO
Transcriptomics RNA-seq analysis of BAP1-depleted uveal melanoma cells
2018-10-15 | GSE110193 | GEO
Transcriptomics Global expression analysis of BAP1 knockdown in transfected 92.1 cells
2011-01-06 | E-GEOD-24896 | biostudies-arrayexpress
Genomics Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status
2016-06-06 | GSE79905 | GEO
Transcriptomics Gene expression analysis of uveal melanoma tumor tissue
2012-07-30 | E-GEOD-39717 | biostudies-arrayexpress
Methylation profiling BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas [MethylationEPIC]
2020-04-04 | GSE130295 | GEO
Transcriptomics BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas [RNA-Seq]
2020-04-04 | GSE130356 | GEO
Methylation profiling BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas [BeadChip 450K]
2020-04-04 | GSE130354 | GEO
Transcriptomics Expression data from BAP1 depleted cells
2010-11-05 | E-GEOD-23035 | biostudies-arrayexpress
Transcriptomics RNA-seq analysis of BAP1 mutant and wild-type uveal melanoma cell lines
2022-04-25 | GSE181194 | GEO