Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: David Cherba
PROVIDER: E-GEOD-50208 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors.
Peacock Jacqueline D JD Cherba David D Kampfschulte Kevin K Smith Mallory K MK Monks Noel R NR Webb Craig P CP Steensma Matthew M
Journal of translational medicine 20130917
<h4>Background</h4>Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A overexpression in these tumors, doxorubicin resistance is common, and the mechanisms of chemotherapy resistance in MPNST are poorly understood. Molecular-guided therapy prediction is an emerging strategy for treatment refractory sarcomas that involves identification of t ...[more]
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