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Epigenome analysis of irradiated and non-irradiated breast tumor tissue samples and normal controls

ABSTRACT: Genome wide DNA methylation profiling of irradiated and non-irradiated breast tumor samples and normal control tissue. The Illumina Infinium 27k Human DNA methylation Beadchip, Genome Build 36 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in breast tumor samples. Samples included 20 non-irradiated tumor samples, 19 irradiated tumor samples and 9 normal controls. Bisulphite converted DNA from the 48 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Ann Rita Halvorsen

PROVIDER: E-GEOD-50220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy.

Halvorsen Ann Rita AR Helland Aslaug A Fleischer Thomas T Haug Karen Marie KM Grenaker Alnaes Grethe Irene GI Nebdal Daniel D Syljuåsen Randi G RG Touleimat Nizar N Busato Florence F Tost Jörg J Saetersdal Anna B AB Børresen-Dale Anne-Lise AL Kristensen Vessela V Edvardsen Hege H

International journal of cancer 20140405 9

Radiotherapy (RT) is a central treatment modality for breast cancer patients. The purpose of our study was to investigate the DNA methylation changes in tumors following RT, and to identify epigenetic markers predicting treatment outcome. Paired biopsies from patients with inoperable breast cancer were collected both before irradiation (n = 20) and after receiving 10-24 Gray (Gy) (n = 19). DNA methylation analysis was performed by using Illumina Infinium 27K arrays. Fourteen genes were selected ...[more]

PMID: 24658971

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2014-05-20 | E-GEOD-57767 | biostudies-arrayexpress

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2014-10-31 | E-GEOD-62867 | biostudies-arrayexpress

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2013-04-04 | E-GEOD-45198 | biostudies-arrayexpress

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-04 | E-GEOD-45200 | biostudies-arrayexpress

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells Methylation Data for In Vitro Model

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2013-04-04 | E-GEOD-45199 | biostudies-arrayexpress

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2015-11-26 | E-GEOD-75414 | biostudies-arrayexpress

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