Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Epigenome analysis of irradiated and non-irradiated breast tumor tissue samples and normal controls


ABSTRACT: Genome wide DNA methylation profiling of irradiated and non-irradiated breast tumor samples and normal control tissue. The Illumina Infinium 27k Human DNA methylation Beadchip, Genome Build 36 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in breast tumor samples. Samples included 20 non-irradiated tumor samples, 19 irradiated tumor samples and 9 normal controls. Bisulphite converted DNA from the 48 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

ORGANISM(S): Homo sapiens

SUBMITTER: Ann Rita Halvorsen 

PROVIDER: E-GEOD-50220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Radiotherapy (RT) is a central treatment modality for breast cancer patients. The purpose of our study was to investigate the DNA methylation changes in tumors following RT, and to identify epigenetic markers predicting treatment outcome. Paired biopsies from patients with inoperable breast cancer were collected both before irradiation (n = 20) and after receiving 10-24 Gray (Gy) (n = 19). DNA methylation analysis was performed by using Illumina Infinium 27K arrays. Fourteen genes were selected  ...[more]

Similar Datasets

2014-05-20 | E-GEOD-57767 | biostudies-arrayexpress
2014-09-11 | E-GEOD-51287 | biostudies-arrayexpress
2012-11-07 | E-GEOD-39141 | biostudies-arrayexpress
2014-10-31 | E-GEOD-62867 | biostudies-arrayexpress
2013-04-04 | E-GEOD-45198 | biostudies-arrayexpress
2013-04-04 | E-GEOD-45200 | biostudies-arrayexpress
2013-04-04 | E-GEOD-45199 | biostudies-arrayexpress
2015-08-27 | E-GEOD-62086 | biostudies-arrayexpress
2015-11-26 | E-GEOD-75414 | biostudies-arrayexpress
2012-05-08 | E-GEOD-36194 | biostudies-arrayexpress