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Gene expression data from 1833 cells and 1833 cells depleted of BACH1 mRNA expression

ABSTRACT: The transcription factor BACH1 is a master regulator of human breast cancer metastasis. Here we use gene expression array analysis to identify and compare the genes regulated by BACH1 depletion in a metastatic human breast cancer cell line. Total RNAs were extracted from vector control 1833 cells or 1833 cells with shBACH mRNA BACH1 depletion. Affymetrix GeneChip Human Gene 1.0 ST Arrays were performed to detail the gene expression and identify the genes regulated by BACH1in metastatic human breast cancer cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Marsha Rosner

PROVIDER: E-GEOD-50226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.

Lee Unjin U Frankenberger Casey C Yun Jieun J Bevilacqua Elena E Caldas Carlos C Chin Suet-Feung SF Rueda Oscar M OM Reinitz John J Rosner Marsha Rich MR

PloS one 20131211 12

Although triple negative breast cancers (TNBC) are the most aggressive subtype of breast cancer, they currently lack targeted therapies. Because this classification still includes a heterogeneous collection of tumors, new tools to classify TNBCs are urgently required in order to improve our prognostic capability for high risk patients and predict response to therapy. We previously defined a gene expression signature, RKIP Pathway Metastasis Signature (RPMS), based upon a metastasis-suppressive s ...[more]

PMID: 24349199

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