Unknown,Transcriptomics,Genomics,Proteomics

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Effect of SRSF2 over-expression in a human lung carcinoma cell line


ABSTRACT: We showed that the over-expression of the SR protein SRSF2 led to the regulation of transcript abundance of many genes. H358 cell line with 6 samples with SRSF2 over-expression and 6 samples as control.

ORGANISM(S): Homo sapiens

SUBMITTER: Laurent Corcos 

PROVIDER: E-GEOD-50467 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies.

Pesson Marine M   Eymin Béatrice B   De La Grange Pierre P   Simon Brigitte B   Corcos Laurent L  

Molecular cancer 20140115


Alternative pre-mRNA splicing (AS) widely expands proteome diversity through the combinatorial assembly of exons. The analysis of AS on a large scale, by using splice-sensitive microarrays, is a highly efficient method to detect the majority of known and predicted alternative transcripts for a given gene. The response to targeted anticancer therapies cannot easily be anticipated without prior knowledge of the expression, by the tumor, of target proteins or genes. To analyze, in depth, transcript  ...[more]

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