Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Vonn Walter
PROVIDER: E-GEOD-58542 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Orvis Tess T Hepperla Austin A Walter Vonn V Song Shujie S Simon Jeremy J Parker Joel J Wilkerson Matthew D MD Desai Nisarg N Major Michael B MB Hayes D Neil DN Davis Ian J IJ Weissman Bernard B
Cancer research 20140812 22
SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian, renal, liver, and pediatric cancers. In particular, approximately 10% of primary human lung non-small cell lung cancers (NSCLC) display attenuations in the BRG1 ATPase, a core fact ...[more]