Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Comparison of gene expression in control and BRG1-knockdown H358 cell lines


ABSTRACT: Transcription was assessed in the human H358 NSCLC cell line after knockdown of BRG1, one of the mutually exclusive subunits of the SWI/SNF chromatin remodeling complex, by 2 different shRNAs. One biolgical replicate of each treatment; 4 technical replicates of each treatment.

ORGANISM(S): Homo sapiens

SUBMITTER: Vonn Walter 

PROVIDER: E-GEOD-58542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.

Orvis Tess T   Hepperla Austin A   Walter Vonn V   Song Shujie S   Simon Jeremy J   Parker Joel J   Wilkerson Matthew D MD   Desai Nisarg N   Major Michael B MB   Hayes D Neil DN   Davis Ian J IJ   Weissman Bernard B  

Cancer research 20140812 22


SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic instability, and DNA repair. Inactivation of this class of chromatin remodeling complex has been associated with a variety of malignancies, including lung, ovarian, renal, liver, and pediatric cancers. In particular, approximately 10% of primary human lung non-small cell lung cancers (NSCLC) display attenuations in the BRG1 ATPase, a core fact  ...[more]

Similar Datasets

2014-01-13 | E-GEOD-54033 | biostudies-arrayexpress
2010-04-22 | E-MEXP-2677 | biostudies-arrayexpress
2014-06-04 | E-GEOD-48298 | biostudies-arrayexpress
2013-08-30 | E-GEOD-50467 | biostudies-arrayexpress
2013-12-31 | E-GEOD-52465 | biostudies-arrayexpress
2013-11-01 | E-GEOD-47146 | biostudies-arrayexpress
2015-09-30 | E-MTAB-3795 | biostudies-arrayexpress
2013-09-03 | E-GEOD-42330 | biostudies-arrayexpress
2012-08-31 | E-GEOD-33959 | biostudies-arrayexpress
2020-05-17 | E-MTAB-7986 | biostudies-arrayexpress