Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maya Kansara
PROVIDER: E-GEOD-50532 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kansara Maya M Leong Huei San HS Lin Dan Mei DM Popkiss Sophie S Pang Puiyi P Garsed Dale W DW Walkley Carl R CR Cullinane Carleen C Ellul Jason J Haynes Nicole M NM Hicks Rod R Kuijjer Marieke L ML Cleton-Jansen Anne-Marie AM Hinds Philip W PW Smyth Mark J MJ Thomas David M DM
The Journal of clinical investigation 20131115 12
Ionizing radiation (IR) and germline mutations in the retinoblastoma tumor suppressor gene (RB1) are the strongest risk factors for developing osteosarcoma. Recapitulating the human predisposition, we found that Rb1+/- mice exhibited accelerated development of IR-induced osteosarcoma, with a latency of 39 weeks. Initial exposure of osteoblasts to carcinogenic doses of IR in vitro and in vivo induced RB1-dependent senescence and the expression of a panel of proteins known as senescence-associated ...[more]