Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression of osteosarcoma cell (U2OS, MG63) lines relative to normal human osteoblasts (HOB)


ABSTRACT: Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions. Cancer-specific changes in gene expression play an essential role in cancer occurrence, and ultimately lead to cancer-related self-sufficiency in growth signals, insensitivity to growth inhibitory signals, evasion of apoptosis, limitless replicative potential, angiogenesis, and metastasis. We aimed to analyse such changes in gene expression related to osteosarcoma. Keywords: Comparative We performed genome-wide comparison of gene expression and identified genes that are differentialy expressed in osteosarcoma (U2OS, MG63) cell lines relative to normal human osteoblasts (HOB)

ORGANISM(S): Homo sapiens

SUBMITTER: Bekim Sadikovic 

PROVIDER: E-GEOD-11414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

In vitro analysis of integrated global high-resolution DNA methylation profiling with genomic imbalance and gene expression in osteosarcoma.

Sadikovic Bekim B   Yoshimoto Maisa M   Al-Romaih Khaldoun K   Maire Georges G   Zielenska Maria M   Squire Jeremy A JA  

PloS one 20080730 7


Genetic and epigenetic changes contribute to deregulation of gene expression and development of human cancer. Changes in DNA methylation are key epigenetic factors regulating gene expression and genomic stability. Recent progress in microarray technologies resulted in developments of high resolution platforms for profiling of genetic, epigenetic and gene expression changes. OS is a pediatric bone tumor with characteristically high level of numerical and structural chromosomal changes. Furthermor  ...[more]

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