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The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth


ABSTRACT: Microarray profiling of GFP-marked epithelial cells isolated by FACS from 1st and 3rd instar wild type and mutant Drosophila larvae. Multiple independent replicates collected for each population/timepoint combination. RNA isolated and amplified from FACS-sorted populations. Hybridized as two-color experiment against a common pooled reference.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Charlie Kim 

PROVIDER: E-GEOD-50540 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth.

Jiang Nan N   Soba Peter P   Parker Edward E   Kim Charles C CC   Parrish Jay Z JZ  

Development (Cambridge, England) 20140612 13


As animals grow, many early born structures grow by cell expansion rather than cell addition; thus growth of distinct structures must be coordinated to maintain proportionality. This phenomenon is particularly widespread in the nervous system, with dendrite arbors of many neurons expanding in concert with their substrate to sustain connectivity and maintain receptive field coverage as animals grow. After rapidly growing to establish body wall coverage, dendrites of Drosophila class IV dendrite a  ...[more]

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