Unknown,Transcriptomics,Genomics,Proteomics

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NK cells and immune memory


ABSTRACT: Microarray profiling of adoptively transferred GFP-marked NK cells during MCMV infection in C57BL/6 mice Multiple independent replicates were collected per time point. NK cells were isolated from spleens of mice by flow cytometry. RNA isolated, amplified, and hybridized as two-color experiment against a common pooled reference.

ORGANISM(S): Mus musculus

SUBMITTER: Charlie Kim 

PROVIDER: E-GEOD-25672 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

NK cells and immune "memory".

Sun Joseph C JC   Lopez-Verges Sandra S   Kim Charles C CC   DeRisi Joseph L JL   Lanier Lewis L LL  

Journal of immunology (Baltimore, Md. : 1950) 20110201 4


Immunological memory is a hallmark of the adaptive immune system. However, the ability to remember and respond more robustly against a second encounter with the same pathogen has been described in organisms lacking T and B cells. Recently, NK cells have been shown to mediate Ag-specific recall responses in several different model systems. Although NK cells do not rearrange the genes encoding their activating receptors, NK cells experience a selective education process during development, undergo  ...[more]

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