Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Adam Sowalsky
PROVIDER: E-GEOD-50630 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sowalsky Adam G AG Xia Zheng Z Wang Liguo L Zhao Hao H Chen Shaoyong S Bubley Glenn J GJ Balk Steven P SP Li Wei W
Molecular cancer research : MCR 20140904 1
<h4>Unlabelled</h4>Men with metastatic prostate cancer who are treated with androgen deprivation therapies (ADT) usually relapse within 2 to 3 years with disease that is termed castration-resistant prostate cancer (CRPC). To identify the mechanism that drives these advanced tumors, paired-end RNA-sequencing (RNA-seq) was performed on a panel of CRPC bone marrow biopsy specimens. From this genome-wide approach, mutations were found in a series of genes with prostate cancer relevance, including AR ...[more]