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MicroRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation

ABSTRACT: MicroRNAs (miRNAs) are small and endogenously expressed non-coding RNAs that negatively regulate the expression of protein-coding genes at the translational level. Emerging evidence suggests that miRNAs play critical roles in central nervous system under physiological and pathological conditions. However, their expression and functions in status epilepticus (SE) have not been well characterized thus far. Here, we characterized miRNA expression profile in rat hippocampus at 24 hours following SE induced by amygdala stimulation. Hippocampus miRNA profiles of experimental group and control group were generated by deep sequencing, using Hiseq 2000.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Zhen Sun

PROVIDER: E-GEOD-50940 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide microRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation identifies modulators of neuronal apoptosis.

Sun Zhen Z Yu Jin-Tai JT Jiang Teng T Li Meng-Meng MM Tan Lin L Zhang Qun Q Tan Lan L

PloS one 20131025 10

MicroRNAs (miRNAs) are small and endogenously expressed non-coding RNAs that negatively regulate the expression of protein-coding genes at the translational level. Emerging evidence suggests that miRNAs play critical roles in central nervous system under physiological and pathological conditions. However, their expression and functions in status epilepticus (SE) have not been well characterized thus far. Here, by using high-throughput sequencing, we characterized miRNA expression profile in rat ...[more]

PMID: 24205215

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