MicroRNA profiles of activated and resting T cells and their exosomes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: VIllaroya Carolina
PROVIDER: E-GEOD-50953 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.
Villarroya-Beltri Carolina C Gutiérrez-Vázquez Cristina C Sánchez-Cabo Fátima F Pérez-Hernández Daniel D Pérez-Hernández Daniel D Vázquez Jesús J Martin-Cofreces Noa N Martinez-Herrera Dannys Jorge DJ Pascual-Montano Alberto A Mittelbrunn María M Sánchez-Madrid Francisco F
Nature communications 20130101
Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells. However, the mechanisms that control the specific loading of RNA species into exosomes remain unknown. Here we describe sequence motifs present in miRNAs that control their localization into exosomes. The protein heterogeneous nuclea ...[more]
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