Unknown,Transcriptomics,Genomics,Proteomics

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MRNA profiles of activated and resting T cells and their exosomes


ABSTRACT: Microarray analysis of exosomal and cellular mRNAs in activated and resting primary human T lymphoblasts Primary human T lymphoblasts were obtained from eight donors and total RNA was isolated from cells and derived exosomes before and after activation with PMA plus ionomycin.

ORGANISM(S): Homo sapiens

SUBMITTER: VIllaroya Carolina 

PROVIDER: E-GEOD-50971 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication. Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells. However, the mechanisms that control the specific loading of RNA species into exosomes remain unknown. Here we describe sequence motifs present in miRNAs that control their localization into exosomes. The protein heterogeneous nuclea  ...[more]

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