Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Motomi Osato
PROVIDER: E-GEOD-51107 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Chelsia Qiuxia CQ Krishnan Vaidehi V Tay Lavina Sierra LS Chin Desmond Wai Loon DW Koh Cai Ping CP Chooi Jing Yuan JY Nah Giselle Sek Suan GS Du Linsen L Jacob Bindya B Yamashita Namiko N Lai Soak Kuan SK Tan Tuan Zea TZ Mori Seiichi S Tanuichi Ichiro I Tergaonkar Vinay V Ito Yoshiaki Y Osato Motomi M
Cell reports 20140724 3
The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bone marrow failure and myeloproliferative disorder. These contradictory clinical manifestations are reminiscent of human inherited bone marrow failure syndromes such as Fanconi anemi ...[more]