Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Margaret Goodell
PROVIDER: E-GEOD-53742 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jeong Mira M Sun Deqiang D Luo Min M Huang Yun Y Challen Grant A GA Rodriguez Benjamin B Zhang Xiaotian X Chavez Lukas L Wang Hui H Hannah Rebecca R Kim Sang-Bae SB Yang Liubin L Ko Myunggon M Chen Rui R Göttgens Berthold B Lee Ju-Seog JS Gunaratne Preethi P Godley Lucy A LA Darlington Gretchen J GJ Rao Anjana A Li Wei W Goodell Margaret A MA
Nature genetics 20131124 1
Gains and losses in DNA methylation are prominent features of mammalian cell types. To gain insight into the mechanisms that promote shifts in DNA methylation and contribute to changes in cell fate, including malignant transformation, we performed genome-wide mapping of 5-methylcytosine and 5-hydroxymethylcytosine in purified mouse hematopoietic stem cells. We discovered extended regions of low methylation (canyons) that span conserved domains frequently containing transcription factors and are ...[more]