Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Claudio Villanueva
PROVIDER: E-GEOD-51223 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Villanueva Claudio J CJ Vergnes Laurent L Wang Jiexin J Drew Brian G BG Hong Cynthia C Tu Yiping Y Hu Yan Y Peng Xu X Xu Feng F Saez Enrique E Wroblewski Kevin K Hevener Andrea L AL Reue Karen K Fong Loren G LG Young Stephen G SG Tontonoz Peter P
Cell metabolism 20130301 3
Transcriptional effectors of white adipocyte-selective gene expression have not been described. Here we show that TLE3 is a white-selective cofactor that acts reciprocally with the brown-selective cofactor Prdm16 to specify lipid storage and thermogenic gene programs. Occupancy of TLE3 and Prdm16 on certain promoters is mutually exclusive, due to the ability of TLE3 to disrupt the physical interaction between Prdm16 and PPARγ. When expressed at elevated levels in brown fat, TLE3 counters Prdm16, ...[more]