Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hee-Woong Lim
PROVIDER: E-GEOD-63965 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genes & development 20150201 3
PR (PRD1-BF1-RIZ1 homologous) domain-containing 16 (PRDM16) drives a brown fat differentiation program, but the mechanisms by which PRDM16 activates brown fat-selective genes have been unclear. Through chromatin immunoprecipitation (ChIP) followed by deep sequencing (ChIP-seq) analyses in brown adipose tissue (BAT), we reveal that PRDM16 binding is highly enriched at a broad set of brown fat-selective genes. Importantly, we found that PRDM16 physically binds to MED1, a component of the Mediator ...[more]