Expression profiling defines a recurrence signature in lung squamous cell carcinoma

ABSTRACT: Lung cancer remains the leading cause of cancer death worldwide. Overall 5-year survival is about 10-15% and despite curative intent surgery, treatment failure is primarily due to recurrent disease. Conventional prognostic markers are unable to determine which patients with completely resected disease within each stage group are likely to relapse. To identify a gene signature associated with recurrent squamous cell carcinoma (SCC) of lung, we analyzed primary tumour gene expression for a total of fifty-one SCCs (stage I-III) on 22,323 element microarrays, comparing expression profiles for individuals who remained disease-free for a minimum of 36 months with those from individuals whose disease recurred within 18 months of complete resection. Cox proportional hazards modeling with leave-one

ORGANISM(S): Homo sapiens

SUBMITTER: Jill Larsen 

PROVIDER: E-GEOD-5123 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress