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Sensitivity to proteasome inhibition and in vivo growth properties of MCL cells

ABSTRACT: MCL cells resistant to bortezomib show distinct tumor growth in vivo when compared to their bortezomib-sensitive counterpart We used microarrays to detail the factors underlying the increased tumorigenicity of bortezomib-resistant cells in vivo Global RNA expression in tumors harvested from SCID mice and derived from either bortezomib-sensitive or bortezomib-resistant MCL cell lines

ORGANISM(S): Homo sapiens

SUBMITTER: Gael Roue

PROVIDER: E-GEOD-51371 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sensitivity to proteasome inhibition and in vivo growth properties of MCL cells

Project description:MCL cells resistant to bortezomib show distinct tumor growth in vivo when compared to their bortezomib-sensitive counterpart We used microarrays to detail the factors underlying the increased tumorigenicity of bortezomib-resistant cells in vivo

2013-10-18 | GSE51371 | GEO

Comparative study of a mTOR inhibitor, a pan-PI3K inhibitor and a dual PI3K/mTOR inhibitor in MCL

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Antitumoral activity of acadesine and rituximab in MCL

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Bortezomib resistance in Mantle Cell Lymphoma (MCL) is associated with plasmacytic differentiation

Project description:Bortezomib-induced resistant MCL cell lines (HBL2 BR and JEKO BR) were generated by continuous cultured of corresponding parental cell lines (HBL2 PT and JEKO PT) with increasing bortezomib concentrations The IC50 of bortezomib of BR cell lines was 80 fold higher than the IC50 of the parental clone for HBL2-BR and 40 fold higher for JEKO-BR.RNA was isolated from cells collected at different time points within the period of one month in triplicate for HBL2 and in duplicate for JEKO subclones. This material was used for gene expression analysis using Affymetrix platform. Keywords: RNA Comparision of gene expression profiling in matched pairs of PT and BR cell lines

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Bortezomib resistance in Mantle Cell Lymphoma (MCL) is associated with plasmacytic differentiation

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MCL-1 Drives a Metabolic Dependency on Fatty Acid Oxidation in Cancer Independent of its Anti-Apoptotic Function

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SOX11 Gene Expression Profiling

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Transcriptional responses of mantle cell lymphoma (MCL) lines to PKC inhibition

Project description:MCL lines (biological replicates) were treated with DMSO or 2.5uM Sotrastaurin for 3hrs This experiment is designed to see if a common set of genes is affected by Sotrastaurin (STN) treatment in STN-sensitive and STN-insensitive MCL lines. MCL cells were seeded in 6well dishes and treated for 3hrs with DMSO or 2.5uM Sotrastaurin

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Transcriptional responses of mantle cell lymphoma (MCL) lines to PKC inhibition

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