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ROR1 Can Interact With TCL1 And Enhance Leukemogenesis in EM-BM-5-TCL1 Transgenic Mice

ABSTRACT: Transcriptome analysis of RNA samples from leukemia cells of ROR1xTCL1 and TCL1 transgenic mice Animals engrafted with ROR1xTCL1 leukemia-cells developed more aggressive disease than mice engrafted with TCL1 leukemia cells. Transcriptome analysis of RNA samples from leukemia ROR1xTCL1 transgenic mice revealed shared common gene expression signatures that were distinct from those of TCL1 leukemia-cells. We performed microarray transcriptome analyses on isolated leukemia cells that developed in ROR1xTCL1 Tg mice (n=4) or TCL1 Tg mice (n=4) using the Affymetrix Mouse Exon 1.0 ST platform. Array data was processed by Affymetrix Exon Array Computational Tool. No techinical replicates were performed.

ORGANISM(S): Mus musculus

SUBMITTER: Emanuela Ghia 

PROVIDER: E-GEOD-51420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice.

Widhopf George F GF   Cui Bing B   Ghia Emanuela M EM   Chen Liguang L   Messer Karen K   Shen Zhouxin Z   Briggs Steven P SP   Croce Carlo M CM   Kipps Thomas J TJ  

Proceedings of the National Academy of Sciences of the United States of America 20131230 2

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen found on chronic lymphocytic leukemia (CLL) B cells, but not on normal adult tissues. We generated transgenic (Tg) mice with human ROR1 regulated by the murine Ig promoter/enhancer. In contrast to nontransgenic littermates, such animals had B-cell-restricted expression of ROR1 and could develop clonal expansions of ROR1(bright)CD5(+)B220(low) B cells resembling human CLL at ≥ 15 mo of age. Because immune-precipita  ...[more]

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