Genomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mark Meyer
PROVIDER: E-GEOD-51515 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation.
Meyer Mark B MB Benkusky Nancy A NA Lee Chang-Hun CH Pike J Wesley JW
The Journal of biological chemistry 20140602 28
The biological effects of 1α,25-dihydroxyvitamin D3 (1,25 (OH)2D3) on osteoblast differentiation and function differ significantly depending upon the cellular state of maturation. To explore this phenomenon mechanistically, we examined the impact of 1,25(OH)2D3 on the transcriptomes of both pre-osteoblastic (POBs) and differentiated osteoblastic (OBs) MC3T3-E1 cells, and assessed localization of the vitamin D receptor (VDR) at sites of action on a genome-scale using ChIP sequence analysis. We ob ...[more]
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