Unknown,Transcriptomics,Genomics,Proteomics

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The Osteoblast to Osteocyte Transition: Epigenetic Changes and Response to the Vitamin D3 Hormone


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Mark Meyer 

PROVIDER: E-GEOD-54784 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone.

St John Hillary C HC   Bishop Kathleen A KA   Meyer Mark B MB   Benkusky Nancy A NA   Leng Ning N   Kendziorski Christina C   Bonewald Lynda F LF   Pike J Wesley JW  

Molecular endocrinology (Baltimore, Md.) 20140530 7


Osteocytes are derived from osteoblast lineage cells that become progressively embedded in mineralized bone. Development of the osteocytogenic cell line IDG-SW3 has enabled a temporal and mechanistic investigation of this process. Through RNA-sequencing analyses, we show that although substantial changes in gene expression occur during the osteoblast to osteocyte transition, the majority of the transcriptome remains qualitatively osteoblast like. Genes either up-regulated or expressed uniquely i  ...[more]

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