Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mark Meyer
PROVIDER: E-GEOD-54784 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
St John Hillary C HC Bishop Kathleen A KA Meyer Mark B MB Benkusky Nancy A NA Leng Ning N Kendziorski Christina C Bonewald Lynda F LF Pike J Wesley JW
Molecular endocrinology (Baltimore, Md.) 20140530 7
Osteocytes are derived from osteoblast lineage cells that become progressively embedded in mineralized bone. Development of the osteocytogenic cell line IDG-SW3 has enabled a temporal and mechanistic investigation of this process. Through RNA-sequencing analyses, we show that although substantial changes in gene expression occur during the osteoblast to osteocyte transition, the majority of the transcriptome remains qualitatively osteoblast like. Genes either up-regulated or expressed uniquely i ...[more]