Anp32e is a histone chaperone that removes H2A.Z from chromatin
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christophe Papin
PROVIDER: E-GEOD-51579 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Obri Arnaud A Ouararhni Khalid K Papin Christophe C Diebold Marie-Laure ML Padmanabhan Kiran K Marek Martin M Stoll Isabelle I Roy Ludovic L Reilly Patrick T PT Mak Tak W TW Dimitrov Stefan S Romier Christophe C Hamiche Ali A
Nature 20140122 7485
H2A.Z is an essential histone variant implicated in the regulation of key nuclear events. However, the metazoan chaperones responsible for H2A.Z deposition and its removal from chromatin remain unknown. Here we report the identification and characterization of the human protein ANP32E as a specific H2A.Z chaperone. We show that ANP32E is a member of the presumed H2A.Z histone-exchange complex p400/TIP60. ANP32E interacts with a short region of the docking domain of H2A.Z through a new motif term ...[more]
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