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Transcription profiling of human arthritic TNF treated synoviocytes

ABSTRACT: Time series of human arthritic synoviocytes treated with TNFalpha.

ORGANISM(S): Homo sapiens

SUBMITTER: Jill Howlin

PROVIDER: E-GEOD-516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays.

Gallagher Joanne J Howlin Jillian J McCarthy Conor C Murphy Evelyn P EP Bresnihan Barry B FitzGerald Oliver O Godson Catherine C Brady Hugh R HR Martin Finian F

FEBS letters 20030901 1-3

The cytokine tumor necrosis factor alpha (TNF-alpha) is a critical effector of the pathogenesis of rheumatoid arthritis (RA). We used oligonucleotide microarray (OM) analysis to assess TNF-alpha-modulated gene expression in cultured primary human synoviocytes in vitro. Genes identified include cytokines and inflammatory mediators, extracellular matrix and adhesion molecules, cell cycle and proliferation related proteins, transcription related proteins, and apoptotic mediators. OM identified 1185 ...[more]

PMID: 12965196

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