Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jill Howlin
PROVIDER: E-GEOD-516 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
FEBS letters 20030901 1-3
The cytokine tumor necrosis factor alpha (TNF-alpha) is a critical effector of the pathogenesis of rheumatoid arthritis (RA). We used oligonucleotide microarray (OM) analysis to assess TNF-alpha-modulated gene expression in cultured primary human synoviocytes in vitro. Genes identified include cytokines and inflammatory mediators, extracellular matrix and adhesion molecules, cell cycle and proliferation related proteins, transcription related proteins, and apoptotic mediators. OM identified 1185 ...[more]