Unknown,Transcriptomics,Genomics,Proteomics

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Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy [GPL6983]

ABSTRACT: STAG2 is a novel UBC tumor suppressor acting through mechanisms that are different from its role to prevent aneuploidy Gene copy number analyses of STAG2 in urinary bladder tumors. R values were extracted from beadstudio and normalised using the pounds method. Log R Ratios were calculated using an average value of R from 200 cases and controls from the Epicuro study. WaviCGH was used to generate copy number calls and log R ratios in the region of STAG2 on the X chromosome were also visualised manually to determine STAG2 loss.

ORGANISM(S): Homo sapiens

SUBMITTER: Enrique Carrillo de Santa Pau 

PROVIDER: E-GEOD-51640 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome and determine patient management. A discovery exome sequencing screen (n = 17), followed by a prevalence screen (n = 60), identified new genes mutated in this tumor coding for proteins involved in chromatin modification (MLL2, ASXL2 and BPTF), cell division (STAG2, SMC1A and SMC1B) and DNA repair (ATM, ERCC2 and FANCA  ...[more]

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