Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from control and GAPLINC knock down human gastric cancer cell lines

ABSTRACT: Transcriptional profiling of comparing control and GAPLINC stable knocking-down human gastric cancer cell lines. Goal was to determine the different gene expression between control and GAPLINC stable knocking-down human gastric cancer cell lines. Control and GAPLINC stable knocking-down human gastric cancer cell lines were prepared for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Ye Hu 

PROVIDER: E-GEOD-51651 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer.

Hu Ye Y   Wang Jilin J   Qian Jin J   Kong Xuan X   Tang Jieting J   Wang Yingchao Y   Chen Haoyan H   Hong Jie J   Zou Weiping W   Chen Yingxuan Y   Xu Jie J   Fang Jing-Yuan JY  

Cancer research 20141002 23

It is increasingly evident that long noncoding RNAs (lncRNA) have causative roles in carcinogenesis. In this study, we report findings implicating a novel lncRNA in gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive long intergenic noncoding RNA), based on the use of global microarray and in situ hybridization (ISH) analyses to identify aberrantly expressed lncRNA in human gastric cancer specimens. GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues.  ...[more]

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