Unknown,Transcriptomics,Genomics,Proteomics

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Identification of the molecular targets of microRNA-181d in murine thymocytes.


ABSTRACT: T cell-specific transgenic expression of microRNA-181d reduced number of immature CD4+CD8+ thymocytes. Microarray analysis was performed to reveal differentially expressed genes between the wild type and microRNA-181d transgenic thymocytes. Whole thymus tissues were isolated from the wild type (C57BL/6) and microRNA-181d transgenic mice (Tg-38 line), followed by total RNA isolation.

ORGANISM(S): Mus musculus

SUBMITTER: Nicolai S.C. van Oers 

PROVIDER: E-GEOD-51778 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transgenic expression of microRNA-181d augments the stress-sensitivity of CD4(+)CD8(+) thymocytes.

Belkaya Serkan S   van Oers Nicolai S C NS  

PloS one 20140109 1


Physiological stress resulting from infections, trauma, surgery, alcoholism, malnutrition, and/or pregnancy results in a substantial depletion of immature CD4(+)CD8(+) thymocytes. We previously identified 18 distinct stress-responsive microRNAs (miRs) in the thymus upon systemic stress induced by lipopolysaccharide (LPS) or the synthetic glucocorticoid, dexamethasone (Dex). MiRs are short, non-coding RNAs that play critical roles in the immune system by targeting diverse mRNAs, suggesting that t  ...[more]

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