Ontology highlight
ABSTRACT:
ORGANISM(S): Schistosoma mansoni
SUBMITTER: Timothy ANDERSON
PROVIDER: E-GEOD-51847 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Science (New York, N.Y.) 20131121 6164
Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally derived second-generation progeny, and identified a single quantitative trait locus (logarithm of odds = 31) on chromosome 6. A sulfotransferase was identified as the causative gene by using RNA interference knockdown and biochemical complementation assays, and we su ...[more]