Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nicolas Picard
PROVIDER: E-GEOD-51935 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Picard Nicolas N Trompf Katja K Yang Chao-Ling CL Miller R Lance RL Carrel Monique M Loffing-Cueni Dominique D Fenton Robert A RA Ellison David H DH Loffing Johannes J
Journal of the American Society of Nephrology : JASN 20131114 3
The thiazide-sensitive NaCl cotransporter (NCC) of the renal distal convoluted tubule (DCT) controls ion homeostasis and arterial BP. Loss-of-function mutations of NCC cause renal salt wasting with arterial hypotension (Gitelman syndrome). Conversely, mutations in the NCC-regulating WNK kinases or kelch-like 3 protein cause familial hyperkalemic hypertension. Here, we performed automated sorting of mouse DCTs and microarray analysis for comprehensive identification of novel DCT-enriched gene pro ...[more]