Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Housheng He
PROVIDER: E-GEOD-52201 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cai Changmeng C He Housheng Hansen HH Gao Shuai S Chen Sen S Yu Ziyang Z Gao Yanfei Y Chen Shaoyong S Chen Mei Wei MW Zhang Jesse J Ahmed Musaddeque M Wang Yang Y Metzger Eric E Schüle Roland R Liu X Shirley XS Brown Myles M Balk Steven P SP
Cell reports 20141204 5
Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) on a large fraction of androgen-stimulated genes. A subset of these AR/LSD1-associated enhancer sites have histone 3 threonine 6 phosphorylation (H3T6ph), and these sites are furthe ...[more]