Telomerase inhibitor TMPyP4 induced gene expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Anjali Verma
PROVIDER: E-GEOD-5226 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species.
Verma Anjali A Halder Kangkan K Halder Rashi R Yadav Vinod Kumar VK Rawal Pooja P Thakur Ram Krishna RK Mohd Farhan F Sharma Abhay A Chowdhury Shantanu S
Journal of medicinal chemistry 20080901 18
Using a combination of in silico and experimental approaches, we present evidence that the G-quadruplex (G4) motif (an alternative higher-order DNA conformation) has regulatory potential. Genome-wide analyses of 99980 human, chimpanzee, mouse, and rat promoters showed enrichment of sequence with potential to adopt G4 (potential G4 or PG4) motifs near transcription start sites (TSS; P < 0.0001), supporting earlier findings. Interestingly, we found >700 orthologously related promoters in human, mo ...[more]
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