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Nfatc1 Orchestrates Aging in Hair Follicle Stem Cells

ABSTRACT: Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quiescent hair follicle stem cells (HFSCs) were FACS-purified for ChIP-sequcencing.

ORGANISM(S): Mus musculus

SUBMITTER: Brice Keyes

PROVIDER: E-GEOD-52328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nfatc1 orchestrates aging in hair follicle stem cells.

Keyes Brice E BE Segal Jeremy P JP Heller Evan E Lien Wen-Hui WH Chang Chiung-Ying CY Guo Xingyi X Oristian Dan S DS Zheng Deyou D Fuchs Elaine E

Proceedings of the National Academy of Sciences of the United States of America 20131126 51

Hair production is fueled by stem cells (SCs), which transition between cyclical bouts of rest and activity. Here, we explore why hair growth wanes with age. We show that aged hair follicle SCs (HFSCs) in mice exhibit enhanced resting and abbreviated growth phases and are delayed in response to tissue-regenerating cues. Aged HFSCs are poor at initiating proliferation and show diminished self-renewing capacity upon extensive use. Only modestly restored by parabiosis, these features are rooted in ...[more]

PMID: 24282298

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