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SOX9: a Stem Cell Transcriptional Regulator of Secreted Niche Signaling Factors

ABSTRACT: Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used RNA-seq to identify SOX9-dependent transcriptional changes and ChIP-seq to identify SOX9-bound genes in HF-SCs. Telogen quiescent hair follicle stem cells (HFSCs) and intefollicular epidermal cells (IFE) were FACS-purified for ChIP-sequcencing and HFSCs for RNA-Sequencing

ORGANISM(S): Mus musculus

SUBMITTER: mingyan lin

PROVIDER: E-GEOD-54424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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SOX9: a stem cell transcriptional regulator of secreted niche signaling factors.

Kadaja Meelis M Keyes Brice E BE Lin Mingyan M Pasolli H Amalia HA Genander Maria M Polak Lisa L Stokes Nicole N Zheng Deyou D Fuchs Elaine E

Genes & development 20140201 4

Hair follicles (HFs) undergo cyclical periods of growth, which are fueled by stem cells (SCs) at the base of the resting follicle. HF-SC formation occurs during HF development and requires transcription factor SOX9. Whether and how SOX9 functions in HF-SC maintenance remain unknown. By conditionally targeting Sox9 in adult HF-SCs, we show that SOX9 is essential for maintaining them. SOX9-deficient HF-SCs still transition from quiescence to proliferation and launch the subsequent hair cycle. Howe ...[more]

PMID: 24532713

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