Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hiroyuki NOBUSUE
PROVIDER: E-GEOD-52334 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature communications 20140226
Cellular differentiation is regulated through activation and repression of defined transcription factors. A hallmark of differentiation is a pronounced change in cell shape, which is determined by dynamics of the actin cytoskeleton. Here we show that regulation of the transcriptional coactivator MKL1 (megakaryoblastic leukemia 1) by actin cytoskeleton dynamics drives adipocyte differentiation mediated by peroxisome proliferator-activated receptor γ (PPARγ), a master transcriptional regulator of ...[more]