Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shiqing Mao
PROVIDER: E-GEOD-52741 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hu Xiao X Zhang Lei L Mao Shi-Qing SQ Li Zheng Z Chen Jiekai J Zhang Run-Rui RR Wu Hai-Ping HP Gao Juan J Guo Fan F Liu Wei W Xu Gui-Fang GF Dai Hai-Qiang HQ Shi Yujiang Geno YG Li Xianlong X Hu Boqiang B Tang Fuchou F Pei Duanqing D Xu Guo-Liang GL
Cell stem cell 20140213 4
Tet-mediated DNA oxidation is a recently identified mammalian epigenetic modification, and its functional role in cell-fate transitions remains poorly understood. Here, we derive mouse embryonic fibroblasts (MEFs) deleted in all three Tet genes and examine their capacity for reprogramming into induced pluripotent stem cells (iPSCs). We show that Tet-deficient MEFs cannot be reprogrammed because of a block in the mesenchymal-to-epithelial transition (MET) step. Reprogramming of MEFs deficient in ...[more]