Unknown,Transcriptomics,Genomics,Proteomics

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Gene Expression Analysis of PDAC tumors

ABSTRACT: Analysis of myofibroblast ablation at the gene expression level of PDAC tumors. Total RNA optained from pancreas of PDAC mice with and without aSMA myofibroblast ablated In addition, late stage aSMA ablated mice were treated with anti-CTLA4 treatment

ORGANISM(S): Mus musculus

SUBMITTER: Valerie LeBleu 

PROVIDER: E-GEOD-52812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the ability to delete αSMA(+) myofibroblasts in pancreatic cancer were generated. Depletion starting at either noninvasive precursor (pancreatic intraepithelial neoplasia) or the PDAC stage led to invasive, undifferentiated tumors with enhanced hypoxia, epithelial-to-mesenchymal transition, and cancer stem cells, with dimin  ...[more]

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