Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat astrocytes treated with epidermal growth factor (EGF)


ABSTRACT: Primary cultures of astrocytes from rat optic nerve heads were treated with EGFR ligand, EGF. Two cell lines from two different rat donors were used. The sister cell cultures were set as control and EGF treated groups. Experiment Overall Design: experiment #1: compared control astrocyte cultures to sister cultures treated with EGF for 4 hours. Experiment Overall Design: experiment #2: compared control astrocyte cultures to sister cultures treated with EGF for 12 hours

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bin Liu 

PROVIDER: E-GEOD-5282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury.

Liu Bin B   Chen Huiyi H   Johns Terrance G TG   Neufeld Arthur H AH  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20060701 28


Modulating the behaviors of reactive astrocytes is a potential therapeutic strategy for neurodegenerative diseases. We found that upregulation and activation of the epidermal growth factor receptor (EGFR) occur in astrocytes after different injuries in optic nerves in vivo. Activation of EGFR regulates genes and cellular processes representing most major markers of reactive astrocytes and genes related with glaucomatous optic neuropathy and other neural disorders. These results suggest that acti  ...[more]

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