Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Bin Liu
PROVIDER: E-GEOD-5282 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Liu Bin B Chen Huiyi H Johns Terrance G TG Neufeld Arthur H AH
The Journal of neuroscience : the official journal of the Society for Neuroscience 20060701 28
Modulating the behaviors of reactive astrocytes is a potential therapeutic strategy for neurodegenerative diseases. We found that upregulation and activation of the epidermal growth factor receptor (EGFR) occur in astrocytes after different injuries in optic nerves in vivo. Activation of EGFR regulates genes and cellular processes representing most major markers of reactive astrocytes and genes related with glaucomatous optic neuropathy and other neural disorders. These results suggest that acti ...[more]