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Expression data from ependymal cell cultures treated with EGF

ABSTRACT: Expression data from ependymal cell cultures treated with EGF

PROVIDER: PRJNA512281 | ENA |

REPOSITORIES: ENA

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Expression data from ependymal cell cultures treated with EGF

Project description:We identified that EGF blocks differentiation of radial glial progenitors into multiciliated cells. We evaluated global changes to ependymal cell culture gene expression profiles during EGF treatment during differentiation.

2019-05-01 | GSE124518 | GEO

Expression data from ependymal cell cultures treated with MLN4924.

Project description:Expression data from ependymal cell cultures treated with MLN4924.

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Expression data from ependymal cell cultures treated with MLN4924.

Project description:We identified that Foxj1 is degraded by the ubiquitin proteasome system. Foxj1 protein is stabilized by the cullin-RING ligase inhibitor MLN4924. We evaluated global changes to ependymal cell culture gene expression profiles during MLN4924 treatment.

2018-02-28 | GSE111182 | GEO

Transcription profiling of rat astrocytes treated with epidermal growth factor (EGF)

Project description:Primary cultures of astrocytes from rat optic nerve heads were treated with EGFR ligand, EGF. Two cell lines from two different rat donors were used. The sister cell cultures were set as control and EGF treated groups. Experiment Overall Design: experiment #1: compared control astrocyte cultures to sister cultures treated with EGF for 4 hours. Experiment Overall Design: experiment #2: compared control astrocyte cultures to sister cultures treated with EGF for 12 hours

2007-11-29 | E-GEOD-5282 | biostudies-arrayexpress

HaCaT cells treated with bleogen pB1 or eGF

Project description:Transcriptome profiling by using RNA-seq was performed on bleogen pB1-treated, EGF-treated, and untreated HaCaT keratinocytes to gain further insights into the wound healing effects of bleogen pB1 and EGF

2022-09-15 | GSE202512 | GEO

Gene expression data from ependymal tumor samples

Project description:Ependymal tumors across age groups have been classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patient outcome. We aimed at establishing a reliable molecular classification using DNA methylation fingerprints and gene expression data of the tumors on a large cohort of 500 tumors. Nine robust molecular subgroups, three in each anatomic compartment of the central nervous system (CNS), were identified. Total RNA from 209 ependymal tumor samples were hybridised to the Affymetrix HG U133 Plus 2.0 microarrays.

2015-05-21 | E-GEOD-64415 | biostudies-arrayexpress

BRB-seq data of murine intestinal organoids treated with 100ng/ml of Egf, Ereg or Nrg1 ligand for 24 h

Project description:Regeneration of the intestinal epithelium is a dynamic process requiring a transient Yap-dependent reprogramming of the epithelium into a fetal-like state. Adjacent stroma, including subepithelial fibroblasts, are believed to coordinate the process, but mechanisms are not well understood. Here, we identify Neuregulin 1 (NRG1) and Epiregulin (EREG) as fibroblast-derived EGF ligands in colon and intestine which are induced during regeneration and capable of supporting the growth of the intestinal epithelium. While EREG stimulated intestinal organoid growth similarly to EGF, NRG1 increased de novo crypt formation. The goal of this experiment was to observe the differences in gene expression profile of stromal-derived EGF ligands EREG and NRG1 on intestinal organoids compared to traditional used EGF. Organoids were derived from intestinal crypts of a WT mice C57BL/6J. To exclude the size differences observed in long term cultures of EREG and NRG1, we first cultured the organoids for three days in normal ENR media, removed exogenous EGF for 24h and added EGF, EREG or NRG1 to the culture medium for 24 hours prior to the RNA isolation. NRG1 treated organoids acquired a fetal/regenerative transcriptome including activation of the Yap pathway and induction of epithelial EGF ligand Ereg and Amphiregulin (Areg) expression, highlighting the dynamic orchestration of the EGF signaling during regeneration.

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Expression data from Low Temperature Plasma-treated primary prostate cultures

Project description:Expression data from Low Temperature Plasma-treated primary prostate cultures

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HaCaT cells treated with bleogen pB1 or eGF

Project description:HaCaT cells treated with bleogen pB1 or eGF

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Expression data from ependymal layer of wild type and FoxJ1 null postnatal male mice

Project description:FoxJ1 dependent gene expression is required for establishment of ependymal cells in the postnatal brain. This data set compares gene expression profiles of wildtype and FoxJ1 null microdissected dissected tissues at multiple postnatal time points. We used microarrays to detail the FoxJ1-dependent programme of gene expression underlying ependymal cell differentiation in the mouse brain.

2009-10-21 | GSE18678 | GEO

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