Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Effect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.

ABSTRACT: Attention deficit hyperactivity disorder (ADHD) is a common psychiatric condition of children with a prevalence of 5-10% worldwide. Up to 30% of adults with a history of childhood ADHD maintain symptoms in later life; these adult ADHD patients are severely impaired in social and professional life due to persistence of ADHD core symptoms like impulsivity, attention deficit and hyperactivity as well as frequently observed co-morbidities like alcohol and drug abuse, major depression, bipolar and personality disorders. Pharmaceutical treatment options include methylphenidate (MPH), which is amongst others an inhibitor of the dopamine transporter and therefore increases dopamine levels in the brain. However, not all ADHD patients are MPH responders with clinical features to distinguish responders and non-responders being not at hand so far. Likewise, neurobiological reasons for drug response are still elusive. Here, we examined the global transcriptional response of MPH on lymphoblastoid cell lines (LCLs) derived from ADHD patients and unaffected controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Claus Scholz 

PROVIDER: E-GEOD-52889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

A preliminary study on methylphenidate-regulated gene expression in lymphoblastoid cells of ADHD patients.

Schwarz Ricarda R   Reif Andreas A   Scholz Claus-Jürgen CJ   Weissflog Lena L   Schmidt Brigitte B   Lesch Klaus-Peter KP   Jacob Christian C   Reichert Susanne S   Heupel Julia J   Volkert Julia J   Kopf Juliane J   Hilscher Max M   Weber Heike H   Kittel-Schneider Sarah S  

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20140827 3

<h4>Objectives</h4>Methylphenidate (MPH) is a commonly used stimulant medication for treating attention-deficit/hyperactivity disorder (ADHD). Besides inhibiting monoamine reuptake there is evidence that MPH also influences gene expression directly.<h4>Methods</h4>We investigated the impact of MPH treatment on gene expression levels of lymphoblastoid cells derived from adult ADHD patients and healthy controls by hypothesis-free, genome-wide microarray analysis. Significant findings were subseque  ...[more]

Similar Datasets

Transcriptomics Effect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
2014-09-05 | GSE52889 | GEO
Transcriptomics Gene expression correlated with inattention and hyperactivity/impulsivity rating scales in Tourette syndrome
2014-06-30 | GSE30470 | GEO
Transcriptomics Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
2012-08-13 | E-GEOD-33619 | biostudies-arrayexpress
Methylation profiling Association of epigenetic differences nominated by monozygotic twins discordant for attention-deficit hyperactivity disorder with their brain structures
2022-01-12 | GSE186339 | GEO
Proteomics Proteomics data reveals Wnt signaling involvement in the hippocampal-dependent behavioral impairment in THRSP-overexpressing ADHD mouse model
2023-01-18 | PXD038525 | Pride
Transcriptomics Methylphenidate exposure induces dopamine neuron loss and activation of microglia in the basal ganglia of mice
2012-08-14 | GSE33619 | GEO
Genomics Genetic Investigations of Attention-Deficit/Hyperactivity Disorder
| PRJNA1114309 | ENA
Genomics Genetic Investigations of Attention-Deficit/Hyperactivity Disorder
| PRJNA1114310 | ENA
Genomics Homo sapiens
| PRJNA1011341 | ENA
Transcriptomics RNA-sequencing data and whole transcriptome analysis from CDH2 knock-in mice, modeling attention-deficit hyperactivity disorder (ADHD)
2021-08-26 | GSE182698 | GEO