Regulation of Ptch1 expression in the limb
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kevin Peterson
PROVIDER: E-GEOD-52939 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.
Lopez-Rios Javier J Duchesne Amandine A Speziale Dario D Andrey Guillaume G Peterson Kevin A KA Germann Philipp P Unal Erkan E Liu Jing J Floriot Sandrine S Barbey Sarah S Gallard Yves Y Müller-Gerbl Magdalena M Courtney Andrew D AD Klopp Christophe C Rodriguez Sabrina S Ivanek Robert R Beisel Christian C Wicking Carol C Iber Dagmar D Robert Benoit B McMahon Andrew P AP Duboule Denis D Zeller Rolf R
Nature 20140618 7507
The large spectrum of limb morphologies reflects the wide evolutionary diversification of the basic pentadactyl pattern in tetrapods. In even-toed ungulates (artiodactyls, including cattle), limbs are adapted for running as a consequence of progressive reduction of their distal skeleton to symmetrical and elongated middle digits with hoofed phalanges. Here we analyse bovine embryos to establish that polarized gene expression is progressively lost during limb development in comparison to the mous ...[more]
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