Unknown,Transcriptomics,Genomics,Proteomics

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Adenovirus promotes host cell anabolic glucose metabolism via MYC activation


ABSTRACT: Adenovirus infection leads to increased glycolytic metabolism in host cells. Expression of a single gene product encoded within the E4 early transcription region, E4ORF1, is sufficient to promote increased glycolytic flux in cultured epithelial cells. E4ORF1 reprograms cellular glucose metabolism by augmenting MYC-dependent transcription of metabolic genes. To gain insight into the mechanism by which E4ORF1 promotes increased glycolytic flux, we conducted a global microarray analysis of changes in RNA expression in MCF10A cells induced to accutely express ORF1 versus an empty vector.

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Graham 

PROVIDER: E-GEOD-52998 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.

Thai Minh M   Graham Nicholas A NA   Braas Daniel D   Nehil Michael M   Komisopoulou Evangelia E   Kurdistani Siavash K SK   McCormick Frank F   Graeber Thomas G TG   Christofk Heather R HR  

Cell metabolism 20140401 4


Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram cellular metabolism have remained elusive. Here, we show that the gene product of adenovirus E4ORF1 is necessary for adenovirus-induced upregulation of host cell glucose metabolism a  ...[more]

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