Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nicholas Graham
PROVIDER: E-GEOD-52998 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Thai Minh M Graham Nicholas A NA Braas Daniel D Nehil Michael M Komisopoulou Evangelia E Kurdistani Siavash K SK McCormick Frank F Graeber Thomas G TG Christofk Heather R HR
Cell metabolism 20140401 4
Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. Although recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram cellular metabolism have remained elusive. Here, we show that the gene product of adenovirus E4ORF1 is necessary for adenovirus-induced upregulation of host cell glucose metabolism a ...[more]